Lyclear Dermal Cream (Permethrin 5%)

Buy Lyclear Dermal Cream (Permethrin 5%) to Clear Scabies and Crab (Pubic) Lice

Lyclear Dermal Cream (Permethrin 5%)
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Lyclear Dermal Cream contains permethrin 5%, a topical treatment for scabies and crab lice (pubic lice). The cream can be applied to the whole body and should be left on for at least 8 hours. One application is usually sufficient to treat an infestation.

Pack Size - 30g

What is Lyclear Dermal Cream?

Lyclear Dermal Cream is a topical treatment used to treat infestations of scabies and crab lice (also known as pubic lice). It contains the active ingredient permethrin (5% w/w), a synthetic insecticide belonging to a group of medicines called pyrethroids. Permethrin works by affecting the nervous system of the mites and lice, causing them to become paralysed and die.

Lyclear is the branded version of permethrin 5% cream. It is available from pharmacies and can be purchased online from Pharmica with fast, discreet delivery.

What is Lyclear Dermal Cream (permethrin) cream used for?

Lyclear Dermal Cream (permethrin) is used to treat two main conditions:

  • Scabies: A contagious skin condition caused by tiny mites (Sarcoptes scabiei) that burrow into the skin, causing intense itching and a raised rash. The rash often appears between the fingers, on the wrists, elbows, armpits and around the waist, though it can affect most areas of the body.
  • Crab lice (pubic lice): Small parasitic insects that are usually found in pubic hair, though they can also be found on other coarse body hair. Symptoms include itching, inflammation and small blue spots or specks of blood on the skin caused by lice bites.

Lyclear: Our Pharmacist's Advice

"One of the most common concerns we hear from customers who have used Lyclear is that the itching continues after treatment. This is entirely normal and can last for up to four weeks. It does not mean the treatment has not worked. The itching is caused by your body's immune response to the remains of the dead mites in the skin, not by an active infestation.

It is also important that everyone in the household is treated at the same time, even if they do not have symptoms, as scabies can take several weeks to become noticeable after initial contact. Wash all bedding and towels at 60°C on the day of treatment and avoid close skin-to-skin contact until treatment is complete."

Ana Carolina Goncalves

Ana Carolina Goncalves

Superintendent Pharmacist

GPhC Number: 2088658

How to apply Lyclear Dermal Cream

Apply a thin layer of Lyclear cream to clean, dry, cool skin. Do not apply the cream immediately after a hot bath or shower, as warm skin may increase absorption and the risk of irritation. The cream should be applied to the entire body from the neck down, paying particular attention to areas where mites are commonly found, such as between the fingers and toes, the wrists, elbows, armpits, around the waist and the genital area.

Leave the cream on the skin for at least 8 hours (for example, overnight), then wash it off thoroughly with soap and water. If you wash your hands during the treatment period, reapply the cream to your hands afterwards.

How long does Lyclear take to work?

Lyclear begins to work on contact with the mites. One application is usually sufficient to treat a scabies infestation, though a second application after 7 to 14 days may be recommended if live mites are still present. It is important to note that itching may continue for up to four weeks after treatment, even when the mites have been successfully eliminated. This is caused by the body's ongoing allergic reaction to the dead mites and eggs remaining in the skin, and does not necessarily indicate that the treatment has not worked.

If you are concerned that the treatment has not been successful, or if new burrows appear after treatment, consult your pharmacist or GP for advice.

Does Lyclear kill scabies eggs?

Yes. Permethrin, the active ingredient in Lyclear, targets both the adult scabies mites and their eggs. This is one of the reasons why a single application is often sufficient to treat an infestation. However, because newly hatched mites may not always be reached by a single treatment, a second application after 7 to 14 days is sometimes recommended as a precaution.

How to stop scabies spreading during treatment

Scabies is highly contagious and spreads through prolonged skin-to-skin contact. To help prevent reinfestation and reduce the risk of spreading the mites to others during treatment:

  • Wash all bedding, towels and clothing at 60°C or higher on the first day of treatment. If possible, tumble dry items on a hot setting.
  • Place items that cannot be washed into a sealed plastic bag for at least 72 hours (3 days) to allow the mites to die.
  • Avoid close physical contact, including sexual contact, until the full course of treatment has been completed.
  • All household members and close contacts should be treated at the same time, even if they do not currently have symptoms, as scabies can take up to 8 weeks to cause symptoms after initial exposure.

Can I buy Lyclear over the counter?

Lyclear Dermal Cream (permethrin 5%) is classified as a pharmacy (P) medicine in the UK. This means it can be purchased from a pharmacy without a prescription, but you will need to consult with a pharmacist to ensure it is suitable for you. You can also buy Lyclear online from Pharmica after completing a short questionnaire, where our pharmacy team will review your order before dispatching it.

What are the side effects of Lyclear?

As with all medicines, Lyclear may cause side effects in some people, though not everyone will experience them. Common side effects include a tingling, prickling or burning sensation on the skin, temporary redness and mild itching at the application site. These effects are usually mild and tend to resolve within 24 hours.

Itching may persist for up to four weeks after treatment. This is a normal response to the dead mites and does not indicate that the infestation is still active. If itching is bothersome, an antihistamine tablet or a soothing moisturiser may help to provide relief.

Do not use corticosteroid creams or ointments during treatment with Lyclear, as these can reduce the body's immune response and may worsen the infestation.

What is post-scabies syndrome?

Post-scabies syndrome refers to the continuation of itching and skin irritation after scabies treatment has been completed and the mites have been eliminated. It is caused by the body's immune reaction to the remains of dead mites and their waste products within the skin, and can last for several weeks. This is a common occurrence and does not mean that the treatment has failed or that reinfestation has occurred.

To help manage post-scabies itching, your pharmacist may recommend an emollient moisturiser, a mild anti-itch cream or an oral antihistamine. If symptoms persist beyond four weeks, consult your GP to rule out reinfestation or other skin conditions.

Ingredients

  • The active ingredient is permethrin (5% w/w).
  • Other ingredients: coconut oil, glyceryl monostearate, macrogol cetyl ether, cetomacrogol 1000, isopropyl myristate, lanolin alcohols/liquid paraffin mixture, butylated hydroxytoluene (E321), glycerol, formaldehyde solution, carbomer, sodium hydroxide and purified water.

 Information Leaflet

Always read the patient information leaflet before commencing treatment.

Written and reviewed by our qualified team

GPhC Number: 2088658

Ana Carolina Goncalves
Authored by: Ana Carolina Goncalves Superintendent
Pharmacist

GPhC Number: 2225869

Rehma Gill
Reviewed by: Rehma Gill Pharmacy
Manager

Find out more about our team of medical content authors and how we ensure the accuracy of our content with our content guidelines.

Content last updated: 28 Apr 2026

Lyclear Reviews

Overall Rating
9.4 / 10
Ratings Distribution
5 stars
36
4 stars
5
3 stars
2
2 stars
0
1 star
1

Based on 44 independent customer reviews taken by Feefo, Google and Trustpilot.

Truspilot logo
Google logo
Feefo logo
"Good service"

Product Review:

Very good

Service Review:

Good service

Review from: Trustpilot

TickVerified Buyer

Product Review:

Excellent

Review from: Feefo

TickVerified Buyer

"Excellent service good quality item…"

Product Review:

Excellent don't what it said very pleased Happy customer

Service Review:

Excellent service good quality item would recommend Happy customer 👍

Review from: Trustpilot

TickVerified Buyer

"Kinda works but you needs loads of them"

Product Review:

Kinda worlds but you needs. Loads

Service Review:

Kinda works but you needs loads of them

Review from: Trustpilot

TickVerified Buyer

"Excellent"

Product Review:

All came as advertised very pleased

Service Review:

Prompt and well delivered

Review from: Feefo

TickVerified Buyer

"Very good service"

Product Review:

Helped me a lot with the issue.
Arrived on time !

Service Review:

Always reliable, sticking with these guys for a while.

Review from: Feefo

TickVerified Buyer

"Very quick delivery service "

Product Review:

Worked as described

Service Review:

Very quick delivery service , great product, great product description ,product ,worked as described

Review from: Trustpilot

TickVerified Buyer

"Economical"

Product Review:

Effective and easy to apply, not to mention economical.

Service Review:

Economical. fast, professional, who could ask for more?

Review from: Trustpilot

TickVerified Buyer

Product Review:

Excellent product and service. Get package left in secure place. Confidentially packaged. Feel so much happier that it is confidential as I live in small village. I work in the local Charity/Thrift shop and it would impact in a negative way. Please do not use my name or address. Very pleased with your service.

Service Review:

Already done this. Please read previous comments.

Review from: Feefo

TickVerified Buyer

Product Review:

Great

Service Review:

Great and fast service

Review from: Feefo

TickVerified Buyer

Discreet service

Discreet Packaging

Your privacy is important to us. That’s why we’ve taken every step to ensure your order arrives in the most discreet way possible.

From start to finish, your purchase is handled with complete confidentiality. You’ll never see our brand name on your bank statement, bills or delivery papers.

All our parcels are sent in plain, unmarked packaging with no logos, no product descriptions and no indication of what’s inside.

Estimated delivery

Signed For 1st Class

£2.90 - Wednesday 13 May

Collect Near You

£3.95 - Wednesday 13 May

Special Delivery 1pm Guaranteed

£5.95 - Wednesday 13 May by 1pm

Special Delivery 9am Guaranteed

£13.95 - Wednesday 13 May by 9am

Same Day Delivery

from £4.95 - Tuesday 12 May

How does it work?

How it works - Consultation

Online consultation

Complete a short questionnaire to check your eligibility for treatment

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How it works - Delivery

Express delivery

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